解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Epigenetic mechanisms participate in the regulation of gene transcription in eukaryotes. Two studies in yeast have revealed an additional mechanism for controlling global gene transcription that is based on an inherited self-perpetuating change in the conformation of two different components of key transcriptional reg...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb0309-241
更新日期:2009-03-01 00:00:00
abstract::Topoisomerase II (Topo II) is required to separate intertwined sister chromatids before chromosome segregation can occur in mitosis. However, it remains to be resolved whether Topo II has any role in checkpoint control. Here we report that when phosphorylated, Ser 1524 of Topo IIalpha acts as a binding site for the BR...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1828
更新日期:2009-02-01 00:00:00
abstract::The Morphogenesis and Cell Behaviour meeting held this fall in Barcelona explored the role of forces, adhesion and oscillations in embryonic morphogenesis. It highlighted the impact of new microscopy methods and modelling approaches on the most recent advances of the field. ...
journal_title:Nature cell biology
pub_type:
doi:10.1038/ncb0109-3
更新日期:2009-01-01 00:00:00
abstract::Apoptosis is induced by caspases, which are members of the cysteine protease family. Caspases are synthesized as inactive zymogens and initiator caspases first gain activity by associating with an oligomeric complex of their adaptor proteins, such as the apoptosome. Activated initiator caspases subsequently cleave and...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1803
更新日期:2008-12-01 00:00:00
abstract::A surprising functional association between TRPM3, a mysterious member of the family of transient receptor potential (TRP) cation channels, and the sulphated version of pregnenolone, 'mother' of all steroid hormones, has been identified. ...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb1208-1383
更新日期:2008-12-01 00:00:00
abstract::Lamina-associated polypeptide (LAP) 2alpha is a chromatin-associated protein that binds A-type lamins. Mutations in both LAP2alpha and A-type lamins are linked to human diseases called laminopathies, but the molecular mechanisms are poorly understood. The A-type lamin-LAP2alpha complex interacts with and regulates ret...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1793
更新日期:2008-11-01 00:00:00
abstract::Organization of chromatin by epigenetic mechanisms is essential for establishing and maintaining cellular identity in developing and adult organisms. A key question that remains unresolved about this process is how epigenetic marks are transmitted to the next cell generation during cell division. Here we provide a mod...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1787
更新日期:2008-11-01 00:00:00
abstract::Proteins essential for vesicle formation by the Coat Protein I (COPI) complex are being identified, but less is known about the role of specific lipids. Brefeldin-A ADP-ribosylated substrate (BARS) functions in the fission step of COPI vesicle formation. Here, we show that BARS induces membrane curvature in cooperatio...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1774
更新日期:2008-10-01 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates embryonic development and tissue homeostasis; however, aberrations of its activity occur in cancer. TGF-beta signals through its Type II and Type I receptors (TbetaRII and TbetaRI) causing phosphorylation of Smad proteins. TGF-beta...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1780
更新日期:2008-10-01 00:00:00
abstract::Individual neurons form specific elaborate dendritic structures that receive presynaptic information. The pattern of dendritic branching is regulated by the microtubule-associated motor protein dynein, which is responsible for the transport of essential endosomes and other organelles into the dendrites. ...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb1008-1131
更新日期:2008-10-01 00:00:00
abstract::The self-perpetuating amyloid isoform, or prion, of the yeast translation termination factor eRF3 modulates programmed translational frameshifting that controls a regulatory circuit determining the polyamine levels in a yeast cell. But it is still unclear whether this effect is adaptive or pathological. ...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb0908-1019
更新日期:2008-09-01 00:00:00
abstract::Mitochondrial function degenerates with ageing and in ageing-related neuromuscular degenerative diseases, causing physiological decline of the cell. Factors that can delay the degenerative process are actively sought after. Here, we show that reduced cytosolic protein synthesis is a robust cellular strategy that suppr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1769
更新日期:2008-09-01 00:00:00
abstract::The Notch1 gene has an important role in mammalian cell-fate decision and tumorigenesis. Upstream control mechanisms for transcription of this gene are still poorly understood. In a chemical genetics screen for small molecule activators of Notch signalling, we identified epidermal growth factor receptor (EGFR) as a ke...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1750
更新日期:2008-08-01 00:00:00
abstract::The actin cytoskeleton has been implicated in restricting diffusion of plasma membrane components. Here, simultaneous observations of quantum dot-labelled FcepsilonRI motion and GFP-tagged actin dynamics provide direct evidence that actin filament bundles define micron-sized domains that confine mobile receptors. Dyna...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1755
更新日期:2008-08-01 00:00:00
abstract::Lamellipodia/ruffles and filopodia are protruding organelles containing short and highly branched or long and unbranched actin filaments, respectively. The microscopic morphology, dynamic development and protein signature of both lamellipodia/ruffles and filopodia have been investigated; however, little is known about...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1745
更新日期:2008-07-01 00:00:00
abstract::Chromosome loss or gain is associated with a large number of solid cancers, providing genomic plasticity and thus adaptability to cancer cells. Numerical centrosome abnormalities arising from centrosome over-duplication or failed cytokinesis are a recognized cause of aneuploidy. In higher eukaryotic cells, the centros...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1735
更新日期:2008-06-01 00:00:00
abstract::It is now well established that stromal interaction molecule 1 (STIM1) is the calcium sensor of endoplasmic reticulum stores required to activate store-operated calcium entry (SOC) channels at the surface of non-excitable cells. However, little is known about STIM1 in excitable cells, such as striated muscle, where th...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1731
更新日期:2008-06-01 00:00:00
abstract::Store-operated Ca(2+) channels (SOCs) are activated in response to Ca(2+) release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca(2+) content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STI...
journal_title:Nature cell biology
pub_type: 新闻
doi:10.1038/ncb0608-639
更新日期:2008-06-01 00:00:00
abstract::Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1). Gene-targeting analyses of either Ang1 or Tie2 in mice reveal a critical role of Ang1-Tie2 signalling in developmental vascular formation. It remains elusive how the Tie2 signalling pathway plays distinct roles i...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1714
更新日期:2008-05-01 00:00:00
abstract::Cancer cells use aerobic glycolysis preferentially for energy provision and this metabolic change is important for tumour growth. Here, we have found a link between the tumour suppressor p53, the transcription factor NF-kappaB and glycolysis. In p53-deficient primary cultured cells, kinase activities of IKKalpha and I...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1724
更新日期:2008-05-01 00:00:00
abstract::Understanding the factors that direct tissue organization during development is one of the most fundamental goals in developmental biology. Various hypotheses explain cell sorting and tissue organization on the basis of the adhesive and mechanical properties of the constituent cells. However, validating these hypothes...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1705
更新日期:2008-04-01 00:00:00
abstract::ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardio...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1696
更新日期:2008-03-01 00:00:00
abstract::The serine/threonine protein kinase Akt is involved in a variety of cellular processes including cell proliferation, survival, metabolism and gene expression. It is essential in vascular endothelial growth factor (VEGF)-mediated angiogenesis; however, it is not known how Akt regulates the migration of endothelial cell...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1695
更新日期:2008-03-01 00:00:00
abstract::In three-dimensional matrices cancer cells move with a rounded, amoeboid morphology that is controlled by ROCK-dependent contraction of acto-myosin. In this study, we show that PDK1 is required for phosphorylation of myosin light chain and cell motility, both on deformable gels and in vivo. Depletion of PDK1 alters th...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1675
更新日期:2008-02-01 00:00:00
abstract::Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-protein complex 'shelterin', thus protecting chromosome ends from DNA repair mechanisms and degradation. Mammalian telomeric chromatin is enriched for the constitutive heterochromatin marks H3K9me3, H4K20me3 and HP1 (refs 2, 3, 4, 5, ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1685
更新日期:2008-02-01 00:00:00
abstract::The remarkable stability of gene expression in somatic cells is exemplified by the way memory of an active gene state is retained when an endoderm cell nucleus is transplanted to an enucleated egg. Here we analyse the mechanism of a similar example of epigenetic memory. We find that memory can persist through 24 cell ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1674
更新日期:2008-01-01 00:00:00
abstract::During mammalian development, neuroepithelial cells function as mitotic progenitors, which self-renew and generate neurons. Although spindle orientation is important for such polarized cells to undergo symmetric or asymmetric divisions, its role in mammalian neurogenesis remains unclear. Here we show that control of s...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1673
更新日期:2008-01-01 00:00:00
abstract::Changes in phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase II (RNAP) are associated with transcription initiation, elongation and termination. Sites of active transcription are generally characterized by hyperphosphorylated RNAP, particularly at Ser 2 residues, whereas inactive or poised genes m...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1663
更新日期:2007-12-01 00:00:00
abstract::Cell division is fundamental for all organisms. Here we report a genome-scale RNA-mediated interference screen in HeLa cells designed to identify human genes that are important for cell division. We have used a library of endoribonuclease-prepared short interfering RNAs for gene silencing and have used DNA content ana...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1659
更新日期:2007-12-01 00:00:00
abstract::The tumour-suppressor gene ATM, mutations in which cause the human genetic disease ataxia telangiectasia (A-T), encodes a key protein kinase that controls the cellular response to DNA double-strand breaks (DSBs). DNA DSBs caused by ionizing radiation or chemicals result in rapid ATM autophosphorylation, leading to che...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1651
更新日期:2007-11-01 00:00:00
abstract::Autophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how Atg proteins control autophagosome formation in mammalian cells remains to be elucidated. Here, we demonstrate that Bif-1 (also known as E...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1634
更新日期:2007-10-01 00:00:00
abstract::The mitochondrial inner membrane is the central energy-converting membrane of eukaryotic cells. The electrochemical proton gradient generated by the respiratory chain drives the ATP synthase. To maintain this proton-motive force, the inner membrane forms a tight barrier and strictly controls the translocation of ions....
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1635
更新日期:2007-10-01 00:00:00
abstract::Treatment of cultured vertebrate neurons with nitric oxide leads to growth-cone collapse, axon retraction and the reconfiguration of axonal microtubules. We show that the light chain of microtubule-associated protein (MAP) 1B is a substrate for S-nitrosylation in vivo, in cultured cells and in vitro. S-nitrosylation o...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1625
更新日期:2007-09-01 00:00:00
abstract::During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes that specify lineage and differentiation status. Among these factors, the transforming growth factor (TGF)-beta family is imp...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb434
更新日期:2007-09-01 00:00:00
abstract::Nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. Here, we discovered an unexpected role for yeast dynein light chain (Dyn2) in the NPC. Dyn2 is a previously undescribed nucleoporin that functions as molecular glue to dimerize and stabilize the Nup82-Nsp1-Nup159...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1604
更新日期:2007-07-01 00:00:00
abstract::BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na(v)1) beta2-subunit (beta2), a type I membrane protein that covalently binds to Na(v)1 alpha-subunits, is a substrate for BACE1 and gamma-secretase...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1602
更新日期:2007-07-01 00:00:00
abstract::Junior researchers are encouraged to gain experience abroad, and for senior scientists, sabbaticals remain popular. France has taken the next step in fostering international exchange, by supporting long-term collaborations with foreign laboratories and by creating research units abroad. ...
journal_title:Nature cell biology
pub_type: 社论
doi:10.1038/ncb0607-613
更新日期:2007-06-01 00:00:00
abstract::When replication forks collapse, Rad3 phosphorylates the checkpoint-clamp protein Rad9 in a manner that depends on Thr 225, a residue within the PCNA-like domain. The physiological function of Thr 225-dependent Rad9 phosphorylation, however, remains elusive. Here, we show that Thr 225-dependent Rad9 phosphorylation by...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1600
更新日期:2007-06-01 00:00:00
abstract::FoxG1 is an evolutionarily conserved, winged-helix transcriptional repressor that maintains progenitor cells in the vertebrate forebrain. How the activity of FoxG1 is regulated is not known. Here, we report that in the developing Xenopus and mouse forebrain, FoxG1 is nuclear in progenitor cells but cytoplasmic in diff...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1573
更新日期:2007-05-01 00:00:00
abstract::The mechanisms that control cell growth during the cell cycle are poorly understood. In budding yeast, cyclin dependent kinase 1 (Cdk1) triggers polarization of the actin cytoskeleton and bud emergence in late G1 through activation of the Cdc42 GTPase. However, Cdk1 is not thought to be required for subsequent growth ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1568
更新日期:2007-05-01 00:00:00